Involvement of Cu-containing amine oxidases in the development of lung pathology in ovalbumin-induced bronchial asthma in guinea pigs

Bronchial asthma is developed as an immune response to allergen challenges accompanied by inflammation and fibrosis implicated in airway remodeling. To reveal the causative implication of Cu-containing amino oxidases semicarbazide-sensitive amine oxidase (SSAO), DAO lysyl (LOX) BA development we used their irreversible inhibitor semicarbazide guinea pig model induced ovalbumin. Semicarbazide was introduced asthmatic animals via drink or inhalation. At 16th week after disease induction, increase activity pro-inflammatory SSAO plasma (1.6 2 times, respectively) observed. The introduction inhalation significantly decreased activities these enzymes compared untreated animals. A considerable­ IL-13 content LOX lung tissue were observed that evidenced pulmonary development. uptake pigs with bronchial led normalization activity. Histological studies confirmed attenuated morphopathological changes lungs Thus, data obtained indicate direct participation studied progression pathological processes atopic well potential use a drug complex anti-asthmatic therapy. Keywords: asthma, histaminase/diamine oxidase, IL-13, nitric oxide, semicarbazide, sensitive